Code |
Diagnosis |
Comment |
Score |
anonymous |
Malignant small round cell tumour, favour desmoplastic small round cell tumour (100%)
|
Tumour cells may be positive for CK, Desmin, EMA, vimentin and NSE.
|
100 |
anonymous |
Malignant neurogenic tumor: Melanotic neuroectodermal tumor (50%). Neuroblastoma (50%)
|
nil
|
50 |
anonymous |
Gastrointestinal stromal tumor (with possible post-Gleevac effect). 80% DDx: Schwannoma. 20%
|
More clinical history should be given in the first place! Is there a history of previous GIST? Treatment?
The Dx of GIST is confirmed with +ve immunostains (CD117 & CD34) while S-100 protein positivity would be more in favour of a schwannoma.
|
20 |
anonymous |
Desmoplastic small round cell tumor, 100%.
|
Confirm by immunohistochemical studies (cytokeratin, desmin and neurone specific enolase all positive.
|
100 |
anonymous |
Small blue round cell tumor, consistent with intra-abdominal desmoplastic small round cell tumor 70%, ddx: small cell carcinoma 30%.
|
Confirm by CK+, NSE+, desmin+, SMA-, EWS-WT1 protein+.
For small cell ca, CK+(punctate perinuclear), chromogranin+, synaptophysin+. Immunostains for other remote ddx eg. lymphoma, undifferentiated ca and melanoma(pigments+).
|
100 |
anonymous |
Desmoplastic small round cell tumor.(100%)
|
Can do cytokeratin, vimentin, desmin and WT1 stains to help diagnosis. Or do RT-PCR for EWS-WT1 fusion gene transcript to confirm diagnosis.
|
100 |
anonymous |
TREATED GASTROINTESTINAL STROMAL TUMOUR -100%
|
nil
|
10 |
anonymous |
Malignant small blue cell tumour
ddx: Neuroblastoma (70%), Ewing's sarcoma/PNET (20%), malignant melanoma (<10%), rhabdomyosarcoma (<10%), small cell carcinoma (<10%)
|
Perform immunohistochemical stain NSE, synaptophysin, chromogranin, neurofilament, CD 99, S-100 protein, HMB 45, BCK, desmin, myoglobin, myogenin
|
60 |
anonymous |
Intra-abdominal desmoplastic small round cell tumour 100%
|
nil
|
100 |
anonymous |
Schwannoma with presence of melanin and cellular area
|
nil
|
10 |
anonymous |
Infiltration by malignant small round cell NEOPLASM
|
The histologic differential diagnoses include desmoplastic small round cell tumour, gastrointestinal stromal tumour and lymphoma. Immunohistochemcial stains like dismin, cytokeratin, NSE, CD34, c-kit and lymphoid markers are suggested for reaching a definitive diagnosis. The hyaline degeneration of subserosa and subserosal vessels is not typical and secondary changes like treatment effect induced by radiotherapy or chemotherapy needs to be considered.
|
60 |
anonymous |
Small cell tumor
|
The differential disgnoses include primitive neuroectodermal tumor, desmoplastic small round cell tumor, small cell melanoma and small cell carcinoma. Suggest performing immunohistochemical study to differentiate - PNET would be postive for CD99, DSRCT for CD99, cytokeratin and smooth muscle markers, melanoma for S100 and HMB45, and small cell carcinoma for CAM5.2.
|
60 |
anonymous |
Dx: small cell tumor. DDx: desmoplastic small round cell tumour and small cell carcinoma. Will perform epithelial, neuroendocrine and muscle marker. 100% Probability
|
nil
|
80 |
anonymous |
Intra abdominal desmoplastic small round cell tumor. 100%.
|
t(11, 22) (p13: q12) cytogenetic finding for confirmation
|
100 |
anonymous |
Small round cell tumor, favour desmoplastic small round cell tumor (100%)
|
Immunohistochemical staining for AE1/AE3, EMA, NSE, desmin, SMA, LCA.
|
100 |