Qap (Anatomical Pathology) 

QAP Peer Review

AP185
Case History: F/55 Right breast mass
Intended diagnosis: DCIS in sclerosing adenosis. Contributed by:USK
Code Diagnosis Comment Score
anonymous Low grade ductal carcinoma in-situ in sclerosing adenosis (100%) nil  100
anonymous Invasive cribriform carcinoma with DCIS component nil  50
anonymous Ductal carcinoma in-situ, low to intermediate grade. Sclerosing adenosis. Focal suspicious of invasion (small glands surrounded by hyalinized stroma) should be excluded by demonstrating presence of myoepithelial cells (+ve p63, actin).  100
anonymous Low to intermediate grade ductal carcinoma in situ (micropapillary and cribriform), close to cauterized margin; ductal papilloma Immunostaining for myoepithelial markers (e.g. p63) to look for stromal invasion.  95
anonymous Ductal carcinoma in situ, low grade(Van Nuys). 100% Actin stain to look for early invasion.  95
anonymous Ductal carcinoma-in-situ, low grade. (100%) nil  95
anonymous R breast mass - Invasive cribriform carcinoma 80% R breast mass - Tubular carcinoma with cribriform DCIS 20% SMA marker to differentiate if the cribriform structures are in-situ or invasive in nature.  80
anonymous Ductal carcinoma in-situ (DCIS) of intermediate grade (2 of 3, van Nguys)(100%), associated with sclerosing adenosis. Margins clear. Perform smooth muscle antigen (SMA) stain to highlight the myoepithelial cells in the sclerosing glands.  100
anonymous Microinvasive ductal carcinoma, low grade, with Extensive ductal carcinoma in situ, low to intermediate grade, abutting Sclerosing adenosis (Carcinoma arising from the latest one?) nil  95
anonymous DUCTAL CARCINOMA IN SITU (100%) nil  95
anonymous DCIS in complex sclerosing lesion 100% Myoepithelial markers (actin, p63) to exclude infiltrating carcinoma ER to help decide if there is DCIS (homogenous staining in DCIS) Assessment of further blocks  100
anonymous Ductal carcinoma-in-situ, intermediate grade (Van Nuys); sclerosing adenosis nil  100
anonymous Intraductal carcinoma with focal infiltrating duct carcinoma nil  50
anonymous Invasive cribriform carcinoma. Probability: 100% nil  50
anonymous Ductal carcinoma in situ, low grade, cribriform type 100% nil  95
anonymous low grade ductal carcinoma in-situ, cribriform type with sclerosing adenosis (100%) Deeper section and p63 to exclude invasion  100