Qap (Anatomical Pathology) 

QAP Peer Review

AP260
Case History: M/25, cord compression at C7 to T1. Debulking of intraspinal tumor
Intended diagnosis: Nodular sclerosis Hodgkin's disease. Contributed by:PKH
Code Diagnosis Comment Score
anonymous Nodular sclerosis Hodgkin lymphoma (100%) Immunostains for CD30, CD15 and PAX-5 to highlight the neoplastic cells.  100
anonymous Nodular sclerosis Hodgkin lymphoma nil  100
anonymous Nodular sclerosis classical Hodgin's lymphoma Need to perform CD3, CD20, CD15, CD30  100
anonymous Classical Hodgkin lymphoma, nodular sclerosis subtype; 100% Confrim by immunohistochemical studies for PAX5 (weak, focal), CD30(+), CD15(+), CD3(-), CD20(-).  100
anonymous HODGKIN'S LYMPHOMA (NODULAR SCLEROSIS type) CONFIRM BY POSITIVITY FOR CD15 AND CD30. CORRELATE WITH ANY NODAL DISEASE.  100
anonymous Hodgkin lymphoma. 100% nil  90
anonymous Nodular sclerosis classical Hodgkin lymphoma 100% nil  100
anonymous Nodular sclerosis Hodgkin's lymphoma (100%) nil  100
anonymous nodular sclerosing Hodgkin's lymphoma nil  100
anonymous Hematolymphoid tumor, differential diagnosis: (1) Nodular sclerosing type, classical Hodgkin disease; (2) Langerhan cell histiocytosis. IHC - CD1a, S-100, Langerin.  80
anonymous Langerhans cell histiocytosis nil  0
anonymous Nodular sclerosis classical Hodgkin lymphoma To be confirmed by immunohistochemistry  100
anonymous Nodular sclerosing Hodgkin lymphoma (90%) Langerhans cell histiocytosis (10%) Immunostaining for CD30, CD1a, S100 will help to establish the diagnosis.  100
anonymous Malignant lymphoma, e.g. Hodgkin’s lymphoma, perform CD30, CD3, CD20, and MPO for granulocytic sarcoma, S100 for Langerhan cell histiocytosis, and special stain to exclude infections (100% probability). nil  60
anonymous Epithelioid haemangioma (angiolymphoid hyperplasia with eosinophilia) 100% nil  0
anonymous Hodgkin lymphoma, nodular sclerosing. nil  100