Qap (Anatomical Pathology) 

QAP Peer Review

AP210
Case History: F/68 Vaginal mass
Intended diagnosis: Superficial cervicovaginal myofibroblastoma. Contributed by:KFT
Code Diagnosis Comment Score
anonymous Benign spindle cell tumour favour peripheral nerve sheath tumour (100%). Differential diagnoses include perineurioma and neurofibroma. To perform immunostains for EMA and S100. Perineurioma is positive for EMA and negative for S100. Neurofibroma is positive for S100 and negative for EMA.  50
anonymous Vagina: Inflammatory myofibroblastic tumor nil  40
anonymous Superficial cervicovaginal myofibroblastoma (100%). Correlate with history of tamoxifen intake and immunohistochemistry of ER/PR and CD34.  100
anonymous Cellular angiofibroma, 100% nil  60
anonymous Neurofibroma. 100% Diagnosis can be confirmed by positivity for S100. For differential, fibroepithelial polyp is +ve for desmin and may show bizarre stromal cells on multiple sections. Angiomyofibroblastoma is +ve for desmin and may show concentric whorls of spindly cells around vessels.  60
anonymous Cellular angiofibroma. (100%) nil  60
anonymous Vagina - Superficial Cervicovaginal Myofibroblastoma 100% nil  100
anonymous Benign spindle cell tumour ddx: Angiomyofibroblastoma (70%), superficial myofibroblastoma (10%), cellular angiofibroma (10%), cellular neurofibroma (10%) Perform immunostain actin, desmin, CD34 and S-100 for differentiation of tumour.  70
anonymous Superficial myofibroblastoma 100% nil  100
anonymous Polypoid Lesion. Differential diagnosis includes A) Fibroepithelial stromal polyp B) Superficial cervicovaginal myifibroblastoma. Favoring more item A. nil  70
anonymous VAGINA, mass - SUPERFICIAL MYOFIBROBLASTOMA (100%) nil  100
anonymous Benign spindle cell tumor, favor superficial cervicovaginal myofibroblastoma Differential diagnoses include neural/nerve sheath tumors like neurofibroma, to be confirmed by immunohistochemistry (desmin, ER and S100 etc).  100
anonymous Spindle cell lesion, DDx solitary fibrous tumor, cellular angiofibroma and myofibroblastoma. Will perform CD34, SMA, Desmin. 100% nil  70
anonymous Differential diagnoses Neurofibromm (80%) Palisaded circumscribed neuroma (20%) nil  50
anonymous Superficial cervicovaginal myofibroblastoma nil  100