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| Code | Diagnosis | Comment | Score |
| anonymous | Hepatoid adenocarcinoma with yolk sac-like appearance (100%) | Tumour cells are AFP +ve and SALL4 +ve. | 100 |
| anonymous | Mix germ cell tumor | nil | 50 |
| anonymous | Adenocarcinoma with yolk sac tumour-like features, suggestive of hepatoid adenocarcinoma (> 90%). | To perform immunostaining for alpha-fetoprotein, glypican-3, SALL-4 (expected positive). Ddx: Metastatic yolk sac tumour, primary yolk sac tumour. | 100 |
| anonymous | Poorly differentiated adenocarcinoma with features of yolk sac tumor and hepatoid carcinoma | Immunohistochemical studies for alpha fetal protein (AFP), SALL4. Correlate with patient serum AFP level. Sample for other possible germ cell components. | 100 |
| anonymous | Hepatoid adenocarcinoma. | Check serum AFP. Exclude secondary from liver. Rare differential is yolk sac tumor. For hepatoid adenocarcinoma, pCEA shows cannalicular staining pattern. Others markers like hepPar-1, AFP and glypican3 may overlap. Sampling for more classic solid trabeular pattern of hepatoid adenocarcinoma. Sampling for usual adenocarcinoma component. | 100 |
| anonymous | Hepatoid adenocarcinoma (100%) | Immunohistochemical stains of HepPar-1 and AFP would highlight those tumor cells | 100 |
| anonymous | Stomach tumour DDX (1)carcinoma with unusual features (high nuclear grade, clear cytoplasm, microcystic and tubulopapillary pattern) -- favor a rare variant of gastric carcinoma 95% (2)Epithelioid AML 5% | Immunomarkers CAM5.2, alpha fetoprotein, synaptophysin, HMB45 | 70 |
| anonymous | Carcinoma (100%), suggestive of hepatoid adenocarcinoma and yolk-sac tumour-like carcinoma | To perform immunostain for alpha fetoprotein to confirm the nature of the eosinophilic globules. | 100 |
| anonymous | High grade malignant tumour. 100% | Differential diagnoses include extragonadal malignant germ cell tumour and adenocarcinoma exhibiting yolk sac tumour-like pattern. Suggest immunohistochemical study for CK, AFP, hCG and CD30. | 70 |
| anonymous | High grade Malignant tumor. Differential diagnosis include 1) Germ cell tumor especially embryonal carcinoma; 2) Poorly differentiated carcinoma either primary or direct extension from adjacent organ; 3) Mixed carcinoma with neuroendocrine feature | Immunostain is very important for diagnosis such as CD30, Cytokeratin markers, Neuroendocrine markers and etc | 50 |
| anonymous | STOMACH (tumour) - HEPATOID ADENOCARCINOMA. | nil | 100 |
| anonymous | Malignant tumor. Differential diagnosis includes adenocarcinoma with hepatoid pattern (80%) and metastatic carcinoma (20%). (Please see comment) | Correlate with clinical and radiological findings to see if there is only one tumor in stomach or if there is history of primary cancer to other primary cancer in the body. Regarding hepatoid adenocarcinoma, they are immunoreactive towards AFP. Increased AFP is noted in serum. | 100 |
| anonymous | Adenocarcinoma with yolk sac tumour differentiation. (100%) | The distinction between gastric yolk sac tumour and adenocarcinoma with yolk sac tumour differentiation is controversial. Immunohistochemical staining for alpha-fetoprotein (AFP) would be performed. | 100 |
| anonymous | malignant, favor adenocarcinoma with yolk sac tumour component (100%) | perform immunostaining for AFP, Glypican-3 and SALL4 to delineate the yolk sac tumour component; correlate with clinical and serologic findings | 100 |
| anonymous | MALIGNANT TUMOR, differential diagnoses of YOLK SAC TUMOR vs POORLY DIFFERENTIATED CARCINOMA. (100% probability). Immunohistochemistry and clinical correlation. Yolk sac tumor positive for PLAP and alpha fetoprotein. | nil | 100 |
| anonymous | Adenocarcinoma with Yolk sac / trophoblastic component | nil | 100 |
| anonymous | Gastric hepatoid adenocarcinoma 100% | Hep-Par 1, alpa-foetal protein, and alpha-1-antitrypsin. | 100 |
| anonymous | Adenocarcinoma with yolk sac tumour-like pattern. | nil | 100 |