Qap (Anatomical Pathology) 

QAP Peer Review

AP93
Case History: Chronic renal failure. Perforation of descending colon.
Intended diagnosis: Amyloidosis , ulecration and perforation of colon. Contributed by:FML
Code Diagnosis Comment Score
anonymous Amyloidosis and ulcer (100%) Section shows small intestinal wall and adhering diverticulum-like structure. Extensive mucosal ulceration is seen in the latter. Scanty atypical stromal cells are seen. Suggest investigate for Cytomegaloviral infection with immunohistochemical stain. Amyloid deposit is seen in vessel wall of small intestine. Advise Congo red stain for confirmation. Please correlate clinically and with gross finding to see if the descending colon perforation is related to the pathology mentioned above.  100
anonymous Amyloidosis 100% The amyloid is mainly present in the vessel wall. Presence of amyloid can be confirmed by Congo red stain and its characteristic apple green birefringence under polarised microscopy.  100
anonymous DESCENDING COLON : AMYLOIDOSIS; PERITONITIS consistent with PERFORATION. ( 100% ) Special stains including Congo red should be performed and examined under polarized light. The amyloidosis may be related to chronic renal failure or haemodialysis, however, other possibilities including myeloma should also be considered. The ulcer shows many relatively mature plasma cells with occasional binucleated forms. It is likely to be reactive in nature. However, immunocytochemistry for light chain restriction may be performed if indicated.  100
anonymous Amyloidosis No comment.  100
anonymous Amyloidosis 100%, with plasma cell infiltration Confirm amyloidosis with congo red stain. Immunostaining with Kappa/Lambda light chain to rule out plasmacytoma/myeloma  100
anonymous Descending colon - perforated ulcer. Small bowel - amyloidosis. 100% - Further sampling may show amyloidosis in the colon itself. - Congo red for amyloid and immunostain for beta 2-microglobulin to confirm the nature of the deposits. - One mechanism for amyloid-induced ulcer in the GI tract is ischaemia.  100
anonymous Amyloidosis. 100% Confirm by Congo red stain with apple green birefrigence under polarized light.  100
anonymous Amyloid deposits in blood vessels with ischaemic perforation of colon 100% Congo red stain for confirmation To correlate with history (? any haemodialysis)  100
anonymous Amyloidosis (100%) Congo Red to confirm.  100
anonymous Secondary amyloidosis & colonic perforation 100% suggest clinical correlation with history of haemodialysis  100
anonymous Amyloidosis & probable cytomegalovirus infection - 100% Suggest Congo red stain for amyloid & immunopeoxidase stain for CMV  100
anonymous Ulcer with CMV infection (inside endothelial cells) 100% Also present are amorphous eosinophilic materials in occasional small venular wall, suggestive of amyloid (related to CRF) 100% Immunohistochemical studies for further support. Special stains (Congo Red, etc.) for amyloid.  100
anonymous Amyloidosis 100% Immunohistochemistry may be used to characterize the nature of the amyloid protein, and history if hemodialysis for chronic renal failure and high circulating beta2-microglobulin in serum indicate hemodialysis-associated amyloidosis.  100
anonymous Amyloidosis leading to vasculopathy & bowel perforation. Probability 100% - Confirm with special stains : Congo-red, crystal violet. - Should consider whether the cause of renal failure is due to amyloidosis. If the cause of renal failure is not amyloidosis, the amyloid seen may be related to accumulation of B-2 microglobulin secondary to chronic renal failure.  100
anonymous INTESTINE - AMYLOIDOSIS (100%) Suggest confirmation by Congo red stain.  100