Qap (Anatomical Pathology) 

QAP Peer Review

AP141
Case History: F/67, history of carcinoma of breast on Tamoxifen; had undergone surgery, chemotherapy and radiotherapy. Now has anemia of 8.4 g/dl, normochromic normocytic.
Intended diagnosis: Bone Marrow: Metastatic carcinoma from breast. Contributed by:PKH
Code Diagnosis Comment Score
anonymous Metastatic carcinoma (100%) Metastatic lobular carcinoma or ductal carcinoma have to be considered. Focal small tubule formation is seen in tumour cells in this biopsy. Correlation with previous breast excision pathology +/- immunostain for E-Cadherin is advised.  100
anonymous Malignant cells present, consistent with metastatic lobular carcinoma from breast origin (100%) nil  100
anonymous Metastatic carcinoma, consistent with breast primary. 100% nil  100
anonymous Metastatic adenocarcinoma, suggestive of lobular carcinoma of breast Confirm carcinoma by cytokeratin staining, BRST-2 for possible breast primary, and negative E-cadherin for lobular carcinoma of breast  100
anonymous Metastatic carcinoma compatible with a breast primary. 100% nil  100
anonymous Metastatic carcinoma, in keeping with breast primary. Megaloblastoid changes (ineffective erythropoiesis) of marrow. (100%) Do epithelial stain, e.g. AE1/3, to confirm presence of metastatic carcinoma.  100
anonymous Bone marrow trephine - 1.metastatic lobular carcinoma of breast 2.megaloblastic anemia (100%) 1.Carcinoma cells can be highlighted by cytokeratin immunstain. 2.Megaloblastic anemia can be related to chemotherapy, although it is worth excluding Vitamin B12/folate deficiency.  100
anonymous Metastatic adenocarcinoma with features consistent with chemotherapy changes, 100%. Correlate clinically the temporal relationship of chemotherapy and this biopsy.  100
anonymous metastatic carcinoma, suggestive of lobular carcinoma of breast 100% nil  100
anonymous Metastatic carcinoma probably from a breast primary. (100%) nil  100
anonymous Hypercellular marrow with malignant infiltration and erythroid hyperplasia. Features compatible with metastatic adenocarcinoma, most likely of breast origin (100%) nil  100
anonymous Suspicious of malignancy. Would perform epithelial markers to confirm metastatic carcinoma. Probability: 100% nil  100
anonymous Hypercellular marrow with metastatic carcinoma (100%); co-existing changes of megaloblastic anaemia. Perform immunohistochemical stain for cytokeratin to confirm presence of carcinoma cells. The discohesive and vacuolated nature of the cells suggest metastatic lobular carcinoma: correlation with previous histology and immunostain for E-cadherin are helpful. The marrow also shows megaloblastic features, probably related to chemotherapy; myelodysplastic syndrome has to be excluded.  100
anonymous myeloproliferative disorder of non CML type and serous atropthy. would do cytokeratin to exclude a metastatic carcinoma.  100
anonymous Metastatic carcinoma nil  100