|
| Code | Diagnosis | Comment | Score |
| anonymous | Malignant (100%) including yolk sac tumour (90%), differential diagnosis like atypical carcinoid and solitary fibrous tumour with high grade malignant morphology(10%) | Focal microcystic pattern suggests yolk sac tumour. Focal haemangiopericytoma-like vascular pattern raises the possibility of atypical carcinoid and solitary fibrous tumour. Immunostain panel should include alpha-fetoprotein, neuroendocrine marker and CD34. Correlation with serum AFP level is also useful. No other germ cell tumour component is seen. | 100 |
| anonymous | Germ cell tumour (100%) | AFP and HCG may be positive. | 60 |
| anonymous | Yolk sac tumor. (100%) | Correlate with blood alpha-fetoprotein level, as well as other germ cell tumor serological markers. The possibility of other components of germ cell tumor present elsewhere in the tumor should be made known to the clinicians. | 100 |
| anonymous | Malignant tumor, suggestive of yolk sac tumor (100%) | Immunostaining for AFP, correlated with serologic AFP assay | 100 |
| anonymous | Malignant tumor. 100%. Differential include germ cell tumor(yolk sac tumor), carcinoid, lymphoma, thymoma. | Do immunostains: AFP, neuroendocrine markers, lymphoma markers, CD20, Tdt etc. | 80 |
| anonymous | Yolk sac tumor. (100%) | The tiny fragmented biopsy may not represent the whole lesion. Other germ cell component, though not present in the specimen, cannot be completely excluded. Yolk sac tumor is usually positive for AFP stain and negative for CD30, hCG and PLAP stains. | 100 |
| anonymous | Malignant neoplasm 100% | Differential diagnosis includes: germ cell tumour (esp. yolk sac tumour), thymic carcinoma or least likely sarcoma. Definitive tumour typing requires more tissue examination and immunostaining (cytokeratin, aFP etc). | 80 |
| anonymous | Germ cell tumour, favour yolk sac tumour (100%) | To be confirmed by alpha fetoprotein immunohistochemically. Need more blocks to rule out other germ cell component. Correlate with serum biochemical markers like alpha fetoprotein, HCG and LDH. | 100 |
| anonymous | Yolk Sac Tumour 100% | nil | 100 |
| anonymous | YOLK SAC TUMOR. This tumor is immunoreactive for AFP. 100% | nil | 100 |
| anonymous | Malignant tumour: ddx - (1) Neuroendocrine tumour (50%), (2) Yolk sac tumour (50%) | To be confirmed by immunohistochemistry: (1) Neuroendocrine tumour (e.g. atypical carcinoid, medullary thyroid carcinoma): neuroendocrine markers + (2) Yolk sac tumour: alpha-fetoprotein +, need to correlate with clinical findings to exclude metastasis | 80 |
| anonymous | Endodermal sinus tumor | The tumor has a multicystic pattern consistent with endodermal sinus tumor and rare intracellular and intercellular hyaline deposits. Additional sections should be taken to look for Schiller-Duval bodies. Immunohistochemical staining for alpha-fetoprotein and alpha-1-antitrypsin can be done. | 100 |
| anonymous | Malignant Neoplasm, DDx: yolk sac tumor, PNET. Probability: 100% | Perform CD99, synaptophysin for PNET; PLAP and cytokeratin for yolk sac tumor. | 80 |
| anonymous | Yolk sac tumour 100% | Correlate with serum AFP level | 100 |
| anonymous | yolk sac tumour | nil | 100 |