Qap (Anatomical Pathology) 

QAP Peer Review

AP252
Case History: M/60 NPC, Dermatomyositis, MRI brain showed bilateral white matter lesions, brain biopsy
Intended diagnosis: Progressive multifocal leukoencephalopathy. Contributed by:KFT
Code Diagnosis Comment Score
anonymous Progressive multifocal leukoencephalopathy (PML) (100%) Polyomavirus particles can be identified on electron microscopy or by in-situ hybridization. Also perform immunostain to exclude coexisting toxoplasmosis.  100
anonymous Metastatic carcinoma nil  0
anonymous Progressive multifocal leukoencephalopathy Correlate with microbiology investigations. Diagnosis of JC viral infection is normally confirmed with CSF PCR.  100
anonymous demyelinating disease, compatible with progressive multifocal leukoencephalopathy nil  100
anonymous Consistent with PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY. 100% Diagnosis to be confirmed by immunostains, ISH or EM for JC virus and SV40 virus. Less likely ddx of herpes encephalitis excluded by immunostains or ISH. Remote ddx of cryptococcus excluded by mucicarmine stain. Radiation induced necrosis also a remote ddx after exclusion of infection.  100
anonymous Progressive multifocal leukoencephalopathy.(100%) nil  100
anonymous Brain - Progressive multifocal leukoencephalopathy 100% Scattered oligodendroglial cells bearing nuclear changes, compatible with JC virus infection  100
anonymous Consistent with post-irradiation effect and demyelination. nil  80
anonymous Demyelinating disease, 100%, consisting with Progressive multifocal leukoencephalopathy nil  100
anonymous Progressive multifocal leukoencephalopathy with presence of viral inclusions consistent with JC papova virus. nil  100
anonymous Radiation change nil  50
anonymous Demyelination with atypical cells, suggestive of progressive multifocal leukoencephalopathy 1. Suggest immunostaining for JC virus 2. Differential diagnoses are demyelination as a paraneoplastic syndrome, and radionecrosis. Need to correlate with history of radiation and exact site of lesions.  100
anonymous Progressive multifocal leukoencephalopathy (100%) Clinical and radiologic correlation to differentiate from radionecrosis.  100
anonymous Brain: Progressive multifocal leukoencaphalopathy, perform PAS, Ziehl Neelsen and Grocott stains to rule out infective lesions like Whipple’s disease, TB, and fungal infection. (100% probability) nil  100
anonymous Subacute hemorrhagic infarction related to irradiation 100% To exclude infective cause by special stains: Grocott and ZN.  50
anonymous Progressive multifocal leukoencephalopathy to be confirmed with immunostain for JC virus  100