Code |
Diagnosis |
Comment |
Score |
anonymous |
High grade sarcoma (100%), differential diagnoses include malignant fibrous histiocytoma, pleomorphic liposarcoma etc.
|
To sample more blocks to look for better differentiated areas and to perform immunostains including S100, actin, desmin, CD34 to determine the nature of the tumour.
|
100 |
anonymous |
High grade sarcoma (pleomorphic sarcoma)
|
nil
|
100 |
anonymous |
Undifferentiated high grade pleomorphic sarcoma. DDx malignant melanoma, MPNST, sarcomas (osteosarcoma, leiomyosarcoma, liposarcoma and rhabdomyosarcoma).
|
Additional sections to be examined.
A panel of immunostains would include S-100 protein, muscle markers (desmin, actin, myogenin) and HMB45.
|
100 |
anonymous |
Malignant spindle cell tumor; please see comment
|
Immunostaining for follicular dendritic cell markers (CD21/35); myoid markers (actin, desmin, for leiomyosarcoma); S100 for MPNST/ melanoma/ interdigitating dendritic cells sarcoma;
Further sampling for areas of well-differentiated liposarcoma (for de-differentiated liposarcom)
If no definite lineage demonstrated : malignant fibrous histiocytoma.
|
100 |
anonymous |
Undifferentiated malignant tumor consistent with malignant fibrous histiocytoma, pleomorphic-storiform subtype. 100%
|
Immunostains to exclude possible line of differentiation eg. CK, S100, LCA, desmin, actin etc.
There is some suggestion of dedifferentiation. Suggest extensive sampling to look for better differentiated areas.
|
100 |
anonymous |
High grade sarcoma (with malignant fibrous histiocytoma pattern) arising from low grade sarcoma. (100%)
|
Sample more blocks for hints of differentation, e.g. lipoblasts for liposarcoma; striation for skeletal muscle; cartilage for chondroid; nerve sheath for malignant peripheral nerve sheath tumor. Do immunostains to help differentiating the primary lesion. Desmin & actin for smooth muscle; myogenin for skeletal muscle; S100 protein for nerve sheath; CD31 for endothelial; CD34 for others.
|
100 |
anonymous |
Right thigh mass - High grade pleomorphic sarcoma, MFH-like, with leiomyosarcoma area 100%
|
Thorough sampling of tumor required. To correlate with immunostains results for actin, desmin and S100 protein. It is possibe that the MFH part arises from de-differentiation of lower grade part of leiomyosarcoma.
|
100 |
anonymous |
High grade sarcoma (100%)
|
To examine more blocks to look for evidence of differentiation +/- dedifferentiated areas.
Perform immunohistochemical studies for tumour typing :
Smooth and skeletal muscle: SMA, Desmin, myoD1, myogenin
Neural and lipomatous : S100
Epithelial: BCK
|
100 |
anonymous |
High grade sarcoma: Pleomorphic malignant fibrous histiocytoma VS Pleomorphic liposarcoma
|
nil
|
100 |
anonymous |
Pleomorphic MALIGNANT FIBROUS HISTIOCYTOMA (100%)
|
Immunohistochemical stains including pan-cytokeratin, S-100, muscle-specific actin, desmin, CD31, CD34 to rule out specific tumor differentiation.
|
100 |
anonymous |
Pleomorphic sarcoma 100%
|
CD21/35 to exclude FDC sarcoma
SMA/desmin for leiomyosarcoma
S100 for MPNST
|
100 |
anonymous |
High grade pleomorphic sarcoma
|
Possiblities include pleomorphic rhabdomyosarcoma, dedifferentiated liposarcoma, malignant peripheral nerve sheath tumor etc. Suggest taking more blocks, immunohistochemistry and electron microscopy to differentiate.
|
100 |
anonymous |
Undifferentiated sarcoma, consistent with pleomorphic MFH
|
nil
|
100 |
anonymous |
Sarcoma with dedifferentiation.
Do S100 protein for neurogenic sarcoma, do desmin, SMA, myo-D1 to exclude rhabdomyosarcoma, leiomyosarcoma. Do CD34. Probability: 100%
|
nil
|
95 |
anonymous |
Pleomorphic sarcoma (100%), favour malignant fibrous histiocytoma (MFH) (95% probability), pleomorphic rhabdomyosarcoma (5%)
|
Perform MyoD1 immunostain to exclude pleomorphic rhabdomyosarcoma
|
100 |
anonymous |
High grade sarcoma (100%), suggestive of malignant peripheral nerve sheath tumour
|
Immunohistochemical for S-100 protein, SMA, desmin and myogenin.
|
95 |