|
| Code | Diagnosis | Comment | Score |
| anonymous | High grade sarcoma (100%), differential diagnoses include malignant fibrous histiocytoma, pleomorphic liposarcoma etc. | To sample more blocks to look for better differentiated areas and to perform immunostains including S100, actin, desmin, CD34 to determine the nature of the tumour. | 100 |
| anonymous | High grade sarcoma (pleomorphic sarcoma) | nil | 100 |
| anonymous | Undifferentiated high grade pleomorphic sarcoma. DDx malignant melanoma, MPNST, sarcomas (osteosarcoma, leiomyosarcoma, liposarcoma and rhabdomyosarcoma). | Additional sections to be examined. A panel of immunostains would include S-100 protein, muscle markers (desmin, actin, myogenin) and HMB45. | 100 |
| anonymous | Malignant spindle cell tumor; please see comment | Immunostaining for follicular dendritic cell markers (CD21/35); myoid markers (actin, desmin, for leiomyosarcoma); S100 for MPNST/ melanoma/ interdigitating dendritic cells sarcoma; Further sampling for areas of well-differentiated liposarcoma (for de-differentiated liposarcom) If no definite lineage demonstrated : malignant fibrous histiocytoma. | 100 |
| anonymous | Undifferentiated malignant tumor consistent with malignant fibrous histiocytoma, pleomorphic-storiform subtype. 100% | Immunostains to exclude possible line of differentiation eg. CK, S100, LCA, desmin, actin etc. There is some suggestion of dedifferentiation. Suggest extensive sampling to look for better differentiated areas. | 100 |
| anonymous | High grade sarcoma (with malignant fibrous histiocytoma pattern) arising from low grade sarcoma. (100%) | Sample more blocks for hints of differentation, e.g. lipoblasts for liposarcoma; striation for skeletal muscle; cartilage for chondroid; nerve sheath for malignant peripheral nerve sheath tumor. Do immunostains to help differentiating the primary lesion. Desmin & actin for smooth muscle; myogenin for skeletal muscle; S100 protein for nerve sheath; CD31 for endothelial; CD34 for others. | 100 |
| anonymous | Right thigh mass - High grade pleomorphic sarcoma, MFH-like, with leiomyosarcoma area 100% | Thorough sampling of tumor required. To correlate with immunostains results for actin, desmin and S100 protein. It is possibe that the MFH part arises from de-differentiation of lower grade part of leiomyosarcoma. | 100 |
| anonymous | High grade sarcoma (100%) | To examine more blocks to look for evidence of differentiation +/- dedifferentiated areas. Perform immunohistochemical studies for tumour typing : Smooth and skeletal muscle: SMA, Desmin, myoD1, myogenin Neural and lipomatous : S100 Epithelial: BCK | 100 |
| anonymous | High grade sarcoma: Pleomorphic malignant fibrous histiocytoma VS Pleomorphic liposarcoma | nil | 100 |
| anonymous | Pleomorphic MALIGNANT FIBROUS HISTIOCYTOMA (100%) | Immunohistochemical stains including pan-cytokeratin, S-100, muscle-specific actin, desmin, CD31, CD34 to rule out specific tumor differentiation. | 100 |
| anonymous | Pleomorphic sarcoma 100% | CD21/35 to exclude FDC sarcoma SMA/desmin for leiomyosarcoma S100 for MPNST | 100 |
| anonymous | High grade pleomorphic sarcoma | Possiblities include pleomorphic rhabdomyosarcoma, dedifferentiated liposarcoma, malignant peripheral nerve sheath tumor etc. Suggest taking more blocks, immunohistochemistry and electron microscopy to differentiate. | 100 |
| anonymous | Undifferentiated sarcoma, consistent with pleomorphic MFH | nil | 100 |
| anonymous | Sarcoma with dedifferentiation. Do S100 protein for neurogenic sarcoma, do desmin, SMA, myo-D1 to exclude rhabdomyosarcoma, leiomyosarcoma. Do CD34. Probability: 100% | nil | 95 |
| anonymous | Pleomorphic sarcoma (100%), favour malignant fibrous histiocytoma (MFH) (95% probability), pleomorphic rhabdomyosarcoma (5%) | Perform MyoD1 immunostain to exclude pleomorphic rhabdomyosarcoma | 100 |
| anonymous | High grade sarcoma (100%), suggestive of malignant peripheral nerve sheath tumour | Immunohistochemical for S-100 protein, SMA, desmin and myogenin. | 95 |