Qap (Anatomical Pathology) 

QAP Peer Review

AP159
Case History: Hypertension on Tenormin, Sjogren syndrome, deranged LFT; ALP 188, AST 101, ALT 108, ANF 1:1280, SMA weakly +ve, AMA -ve, HBV/HCV -ve. Liver biopsy.
Intended diagnosis: Autoimmune cholangitis. Contributed by:MST
Code Diagnosis Comment Score
anonymous Autoimmune liver disease (autoimmune cholangitis 80%, autoimmune hepatitis or overlap syndrome 20%) Please correlate clinically with scoring system for exact classification. Liver biopsy cores show preserved lobular architecture with portal tract expansion by moderate portal inflammatory infiltrate including lymphocytes and plasma cells. Piecemeal necrosis is mild. Bile duct damage is seen. No granuloma is found. Lobular activity is mild. No bridging fibrosis, cirrhosis, rosetting or multinucleated giant cell formation is seen.  90
anonymous Autoimmune cholangitis (100%) nil  100
anonymous Liver: morphologically consistent with Primary biliary cirrhosis, second stage, combining the clinical data: ANF 1:1280, AMA –ve, consistent with autoimmune cholangitis. If responses to low-dose steroids, a define diagnosis can make.  100
anonymous Autoimmune liver disease (autoimmune cholangiopathy, probably with an element of autoimmune hepatitis as suggested by biochemical findings). 100% nil  100
anonymous Autoimmune hepatitis and cholangiopathy These are overlapping autoimmune syndromes.  90
anonymous AUTOIMMUNE CHOLANGITIS. 100% nil  100
anonymous Autoimmune cholangiopathy.(100%) nil  100
anonymous Liver biopsy - autoimmune hepatitis with overlap syndromes 80% Liver biopsy - autoimmune hepatitis 20% Overlap with primary biliary cirrhosis (currently AMA-ve). Granulomas in parenchyma also raised possibility of drug-related hepatitis  70
anonymous Autoimmune cholangiopathy, 100% Need to perform stains such as Masson Trichrome or Chromotrope-aniline blue to look for fibrosis. Clinical correlation also in particular to see the profile of liver function test is necessary. A persistent elevated ALT/AST should raise the possbility of autoimmune hepatitis + autoimmune cholangiopathy (overlap syndrome). Changes secondary to drug reaction should also be excluded.  100
anonymous autoimmune hepatitis nil  30
anonymous Hepatitis granulomata - Primary biliary cirrhosis? Autoimmune hepatitis? Ziehl-Neelsen and Grocott stain to exclude infectious cause.  50
anonymous Autoimmune Cholangitis (100%) nil  100
anonymous Active chronic hepatitis Favour PBC 75% Need special stains for copper and CAP Serology for AMA, viral hepatitis  70
anonymous autoimmune cholangitis 100% nil  100
anonymous Overlap syndrome autoimmune hepatitis/primary biliary cirrhosis nil  90
anonymous Granulomatous and periportal hepatitis, consistent with autoimmune cholangitis (or AMA negative Primary biliary cirrhosis). Probability: 100% Nil  100
anonymous Granulomatous inflammation 100% Differential diagnoses include primary biliary cirrhosis and autoimmune hepatitis. Drug induced hepatitis is also a possibility. Special stains for acid fast bacilli and fungal organisms have to be performed although infective causes are unlikely. Clinical correlation is necessary.  50
anonymous autoimmune cholangitis, stage 1-2 nil  100