Qap (Anatomical Pathology) 

QAP Peer Review

AP294
Case History: M/25 Right testicular tumor
Intended diagnosis: Mixed germ cell tumour with immature teratoma and yold sac tumor / embryonal carcinoma. Contributed by:MW
Code Diagnosis Comment Score
anonymous Non-seminomatous mixed germ cell tumour (100%), predominantly yolk sac tumour, immunostains to look for other components Immunostains for alpha-fetoprotein, HCG, CD30, Oct-3/4,  95
anonymous Mixed germ cell tumor nil  90
anonymous Mixed germ cell tumour Suggest c-kit, CD30, alphafetoprotein and beta-HCG to determine the presence or absence of seminomatous and non-seminomatous components.  90
anonymous Mixed germ cell tumor, with components of yolk sac tumor, immature teratoma. Possible components of seminoma and embryonal carcinoma noted in this block, further work up by immunohistochemistry to confirm presence of embryonal carcinoma (CD30), and seminoma (OCT 3/4). Also perform further sampling to look for additional germ cell tumor components.  100
anonymous Mixed germ cell tumor. Components include seminoma, embryonal carcinoma, immature teratoma with undifferentiated (sarcomatous) stroma. More sampling to look for more definite yolk sac tumor component with the help of AFP stain. Oct3/4 and CD30 to highlight the seminoma and embryonal carcinoma components respectively.  100
anonymous Malignant mixed germ cell tumor (100%) nil  90
anonymous Right testis tumour - Mixed Germ Cell Tumour 100% nil  90
anonymous Mixed germ cell tumour with immature teratoma and yolk sac tumour component extensive sampling to look for other germ cell tumour component  100
anonymous Yolk sac tumour 100% nil  50
anonymous Mixed germ cell tumor, with the following component: immature teratoma (about 60%), yolk sac tumor (about 20%), embryonal carcinoma (about 10%), and seminoma (about 10%). nil  100
anonymous TESTIS, right, section - MIXED GERM CELL TUMOUR consisting of IMMATURE TERATOMA and YOLK SAC TUMOUR nil  100
anonymous Mixed germ cell tumor. nil  90
anonymous Right Testis - Malignant (mixed) germ cell tumour with major component of malignant teratoma, perform immunostains for presence of other components. Examined more blocks from tumor and perform IHC: CD30, EMA for embryonal carcinoma; SALL 4, AFP for yolk sac tumour; bHCG for choriocarcinoma  100
anonymous yolk sac tumour (100%) Extensive sampling to exclude other germ cell tumour component.  50
anonymous mixed germ cell tumour, with immature teratoma and high grade area suggestive of embryonal carcinoma. 100% nil  100
anonymous Mixed germ cell tumour(yolk sac tumour+ seminoma) nil  95
anonymous Mixed germ cell tumour (yolk sac tumour and immature teratoma) 100% nil  100