Qap (Anatomical Pathology) 

QAP Peer Review

AP104
Case History: M80 Local excision of penile skin
Intended diagnosis: Extramammary Paget's disease. Contributed by:FML
Code Diagnosis Comment Score
anonymous Extramammary Paget's disease (100%) nil  100
anonymous Extramammary Paget's disease. 100% To be confirmed by immunostains for cytokeratin; S100 protein and HMB45 to exclude melanoma  100
anonymous Extramammary Paget's disease. 100% nil  100
anonymous Penile SKIN : EXTRAMAMMARY PAGET'S DISEASE (100%) Stromal invasion is suspected focally. Deeper sections are advised for confirmation. In penile skin, the lesion may be purely intraepidermal or associated with an underlying adenocarcinoma.  100
anonymous Extramammary Paget's Disease (70%) Melanoma (30%) The following would be performed: Mucin stains, immunostains for carcinoembryonic antigen and cytokeratins (would be positive in Paget's disease but negative in melanoma) as well as immunostains for S100 and HMB45 (which would be positive in melanoma but negative in Paget's disease)  100
anonymous Extramammary Paget's disease Deeper sections to exclude invasion; To exclude associated tumor including skin adnexal and visceral malignancy.  100
anonymous Extramammary Paget's disease. 100% The diagnosis can be confirmed by positivity for CAM5.2 and negativity for S100,ie excluding melanoma.  100
anonymous Paget's disease nil  95
anonymous Extramammary Paget's Disease 100% Do immunostains: CEA to confirm and S-100 protein to exclude Pagetoid melanoma  100
anonymous Paget's disease, extramammary (100%) nil  100
anonymous Extramammary Paget's Disease 100% nil  100
anonymous Paget's disease 100% nil  95
anonymous Extramammary Paget's Disease 100% nil  100
anonymous Extramammary Paget's disease 100% It is prudent to confirm the diagnosis by immunohistochemical stains: the tumour cells should be postive for cytokeratin and negative for HMB45.  100
anonymous Extramammary Paget's disease 100% nil  100
anonymous Extramammary paget's disease, suspicious of early invasion, no underlying carcinoma. (100%) Have to exclude underlying carcinoma, and carcinoma in adjacent sites.  100
anonymous Extramammary Paget's disease 100% nil  100
anonymous extramammary Paget's disease nil  100