Qap (Anatomical Pathology) 

QAP Peer Review

AP293
Case History: F/56 Lesser curve tumor revealed by OGD and CT scan. ?GIST
Intended diagnosis: Schwannoma and chronic lymphocytic leukemia. Contributed by:PC
Code Diagnosis Comment Score
anonymous Schwannoma (100%) S100 positive  95
anonymous Fibromatosis nil  50
anonymous Schwannoma nil  95
anonymous Schwannoma 100% nil  95
anonymous Schwannoma. 100% Can be confirmed by S100+. Unlikely differential diagnosis include inflammatory myofibroblastic tumor (ALK-1+ in a subset); gastrointestinal stromal tumor (c-kit+).  95
anonymous Schwannoma (100%) with Atypical lymphoid infiltrate expanding lamina propria (100%) Immunohistochemical stain for B-cell and T-cell markers to rule out lymphoma  100
anonymous Gastric tumour - 1.Stromal tumour with ddx of Schwannoma (99%) and GIST (1%). 2.Florid small sized, monotonous looking lymphoid infiltrate in lamina propria and submucosa. Immunostains S100 protein, CD117, more tissue sampling and lymphoid markers study to rule out low grade lymphoma.  100
anonymous Spindle cell tumour, compatible with schwannoma (90%), differential diagnosis include gastrointestinal stromal tumour (10%) To perform immunostains for S-100 protein and c-kit to differentiate schwannoma (S-100 +ve/ c-kit -ve) and gastrointestinal stromal tumour (S-100 -ve/ c-kit +ve)  95
anonymous Schwannoma 100% nil  95
anonymous Schwannoma nil  95
anonymous STOMACH, lesser curve tumour, resection - consistent with SCHWANNOMA (HKCP QAP 2012 R2 AP293) Diagnosis to be confirmed with positive S100 and negative c-kit immunostaining.  95
anonymous Schwannoma nil  95
anonymous Stomach - Schwannoma DDx: inflammatory pseudotumour (inflammatory myofibroblastic tumor) IHC : S100 for schwannoma; ALK, desmin, actin for inflammatory myofibroblastic tumour; CD34, CD117 for GIST  95
anonymous schwannoma (100%) Immunostaining for S100 protein for confirmation.  95
anonymous neurilemmoma, perform S100, and CD117 to exclude GIST. 100% nil  95
anonymous spindle cell neoplasm. ? Schwannoma nil  70
anonymous Schwannoma 100% nil  95