Qap (Anatomical Pathology) 

QAP Peer Review

AP135
Case History: M/26 Ascites
Intended diagnosis: Malignant Mesothelioma. Contributed by:MST
Code Diagnosis Comment Score
anonymous Malignant (100%) Mesothelioma (80%), metastatic adenocarcinoma (20%) In view of young patient age, clinical correlation is essential to see if there are presence of tumour mass and history of asbestos exposure. Immunostain panel should include mesothelial marker (such as Calretinin), BerEP4, MOC-31 and monoclonal CEA.  100
anonymous Acute inflammation with atypical mesothelial proliferation, favour reactive. (90%) nil  25
anonymous Malignant cells present (100%); Mesothelioma (80%) Adenocarcinoma (20%) Check for history of exposure to asbestoes. Immunohistochemical stains for mesothelial cells are helpful in arriving at the correct diagnosis.  100
anonymous Malignant cells seen (100%) Differential diagnoses include carcinoma, mesothelioma and germ cell tumor. Suggest immunohistochemical studies (on cell block) for BerEP4, CEA (+ in carcinoma), Calretinin (+ in mesothelioma) and PLAP (for germ cell tumor).  100
anonymous Adenocarcinoma. 100% nil  50
anonymous Malignant neoplasm, DDx includes malignant mesothelioma, carcinoma, germ cell tumor, malignant lymphoma and melanoma. Immunostains are required for definite differentiation. (100%) Do calretinin and CK5/6 for mesothelioma; AE1/3 for carcinoma (provided that calretinin and CK5/6 are negative); PLAP for germ cell tumor; LCA, CD15, CD30, L26 and polyclonal CD3 for lymphoma; HMB45 and melan A for melanoma.  100
anonymous Atypical cells present, indefinite for malignancy 100% The atypical cells have morphologic features to suggest being mesothelial in nature and immunostaining (CEA, calretinin, BerEP4, CK5/6) will help. The degree of nuclear pleomorphism appears to exceed that for benign reactive change. Biopsy correlation is preferred.  80
anonymous Atypical cells present, indefinite for malignancy 100% The atypical cells have morphologic features to suggest being mesothelial in nature and immunostaining (CEA, calretinin, BerEP4, CK5/6) will help. The degree of nuclear pleomorphism appears to exceed that for benign reactive change. Biopsy correlation is preferred.  80
anonymous Atypical mesothelial cells present (100%) Please correlate with clinical findings for any peritoneal mass. Suggest biopsy if clinically indicated. Confirm the mesothelial cell nature and rule out adenocarcinoma by performing immunostaining for calretinin, CEA, BerEP4, LeuM1 if clot or cell block available.  30
anonymous Malignant cells present. DDX:(1) Malignant mesothelioma 70% (2) Metastatic adenocarcinoma 30% Suggest immunostaining for HBME-1, Calretinin, CEA(polyclonal), BerEp4  100
anonymous ATYPICAL CELLS PRESENT. The diagnostic possibilities are reactive mesothelial cells and carcinoma, probably adenocarcinoma. 100% nil  40
anonymous Atypical mesothelial cells, favour reactive (100%) Possible underlying causes include infection, perforated GI tract, etc.  25
anonymous Atypical mesothelial cells 50% Suspicious for malignancy 50% nil  40
anonymous Suspicious of malignancy. Probability: 100% Perform immunostaining in the clot. BerEP4 +ve in adenocarcinoma, Calretinin and CK5/6 +ve in mesothelial lesion, PLAP +ve in seminoma.  80
anonymous Suspicious cells seen. EM study and immunostainings for mucin, Ber-EP4, calretinin, HBME1, thrombomodulin, CEA and AFP are useful for distinguishing atypical mesothelial cells from metastatic carcinoma.  80
anonymous suspicious of malignancy nil  50