Qap (Anatomical Pathology) 

QAP Peer Review

AP226
Case History: F/50, cervical/vaginal polyp
Intended diagnosis: Mullerian Adenosarcoma. Contributed by:USK
Code Diagnosis Comment Score
anonymous Embryonal rhabdomyosarcoma (100%) Confirm with immunostains for muscle markers, desmin, muscle specific actin, myogenin.  70
anonymous Mixed Muellerian tumor, adenosarcoma nil  100
anonymous Mullerian adenosarcoma with sacromatous overgrowth (100%) nil  100
anonymous Adenosarcoma with sarcomatous overgrowth There is suggestion of heterologous element (rhabdomyosarcomatous) formation, which can be confirmed with immunohistochemistry for desmin, actin, myogenin etc.  100
anonymous High grade sarcoma consistent with adenosarcoma with heterologous element(rhabdomyoblastic differentiation) and sarcomatous overgrowth. 100%. The rhabdomyoblastic differentiation can be confirmed by skeletal muscle markers. Sampling to confirm the high grade sarcomatous component is greater than 25% of the total tumor volume.  100
anonymous Adenosarcoma.(100%) nil  100
anonymous Cervico-vaginal polyp - Mullerian adenosarcoma 100% nil  100
anonymous Adenosarcoma nil  100
anonymous HIGH GRADE SARCOMA 100%, LINE OF DIFFERIENTIATION TO BE DETERMINED BY IMMUNOHISTOCHEMICAL STUDY SUGGEST IMMUNOHISTOCHEMICAL STUDY IE ACTIN, S100 PROTEIN, CD34 FOR FURTHER CLASSIFICATION  70
anonymous Sarcoma botryoides (Embryonal rhabdomyosarcoma). nil  70
anonymous Cervical/vaginal polyp - Malignant spindle cell tumor, probably high-grade sarcoma. Differential diagnoses include spindle cell carcinoma and melanoma. Immunohistochemical stains including cytokeratin and S-100 are suggested for their distinction. The types of high-grade sarcoma include malignant mixed Mullerian tumor and adenosarcoma. Suggest more sections to look for other tumor tissue e.g. glandular component.  80
anonymous High grade spindle cell sarcoma with myoid and botryoides tumor-like morphology, need to consider rhabdomyosarcoma and adenosarcoma nil  80
anonymous Adenosarcoma with sarcomatous overgrowth and heterologous element (100% probability) nil  100
anonymous Malignant mixed mullerian tumour (100%) nil  80
anonymous Adenosarcoma (100%). nil  100